Essay on Hematology - 1016 Words

Paroxysmal Nocturnal Hemoglobinuria (PNH) also known as Marchiafava-Micheli Syndrome (named after Dr. Ettore Marchiafava and Dr. Ferdinando Micheli) For every million people only a few of them will get paroxysmal nocturnal hemoglobinuria which makes this a rare blood disease. Paroxysmal nocturnal hemoglobinuria affects both sexes and all ages equally. Patients with PNH suffer from a faulty or missing PGI-A gene which can be found within the erythrocytes, leukocytes, and thrombocytes. Paroxysmal nocturnal hemoglobinuria is not an inherited disease but is considered an acquired disease because the hematopoietic stem cells over time begin to change and malfunction. This process of cell change is called somatic mutation. Although not all†¦show more content†¦Some recent research has shown that people with PNH may lack the ability for defective cells to undergo a process I like to call â€Å"cell suicide†, but the actual medical term is apoptosis. Doctors have also found that patients are at higher risk to develop leukemia if they are already suffering from PNH, while those on the other end of the spectrum that ha ve had either one of the diseases aplastic anemia or myelodysplastic syndrome (MDS) have a greater chance of developing PNH. Symptoms of Paroxysmal Nocturnal Hemoglobinuria come on quickly and continue to re-occur. They can be triggered by an infection or by putting the body under a large amount of physical stress. 1) Blood clot/s. Forty percent of PNH sufferers will experience a blood clot at some point, and of all the complications associated with this disease thrombosis is the leading cause of death. 2) Pain in the stomach and/or back. 3) Intermittent bouts of dark colored urine occurring most often in the morning. This darkening of morning urine results from an overnight buildup of hemoglobin that has seeped out of dying red blood cells, then blends with blood, and is excreted during urination. 4) Higher risk of infection. 5) Frequent Headaches. 6) Ability to bruise and/or bleed easily. 7) Fatigue and muscle weakness. 8) Very pale skin. 9)Show MoreRelatedClinical Laboratory And Nursing Laboratory1101 Words   |  5 PagesThis department will be Hematology. Hematology tests the whole blood. This includes white blood cell count (leukocytes) and red blood cell count (erythrocytes) and platelets. Hematology department can help detect various diseases by studying the blood. The department studies the appearance of blood cells to detect diseases. Hematology also does complete blood count which is the most common assays in this department. 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